구분

내용

논문명

Longitudinal analysis of memory T cell responses in survivors of Middle East respiratory syndrome

저자정보

Hyoung Shik Shin, Yeonjae Kim, Jihye Kang, Jihye Um, Jun Sun Park, Wan Beom Park, Yeon Sook Kim, Jae Phil Choi, Ji Young Rhee, Joon Sung Joh, Nam Hyuk Cho, Jeong Sun Yang, Joo Yeon Lee, Dong Gyun Lim

학술지명

Clinical Infectious Diseases

개요

Memory T-cell responses were detected in 82%, 75%, 69%, 64%, and 64% of MERS survivors from 1-5 years post-infection, respectively. Although the frequency of virus-specific interferon gamma (IFN-γ)-secreting T cells tended to be higher in moderately/severely ill patients than in mildly ill patients during the early period of follow-up, there was no significant difference among the different clinical severity groups across all time points. While both CD4+ and CD8+ T cells were involved in memory T-cell responses, CD4+ T cells persisted slightly longer than CD8+ T cells. Both memory CD4+ and CD8+ T cells recognized the E/M/N proteins better than the S protein and maintained their polyfunctionality throughout the period examined. Memory T-cell responses correlated positively with antibody responses during the initial 3-4 years but not with maximum viral loads at any time point.

과제정보

[O_2016_009] Clostridium difficile PCR ribotype 018 균주의 분자생물학적 역학분석