구분

내용

논문명

Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection

저자정보

Hye Won Jeong, Se-Mi Kim, Min Kyung Jung, Ji Yun Noh, Ji-Seung Yoo, Eun-Ha Kim, Young-Il Kim, Kwangmin Yu, Seung-Gyu Jang, Juryeon Gil, Mark Anthony Casel, Rollon Rare, Jeong Ho Choi, Hee-Sung Kim, Jun Hyoung Kim, Jihye Um, Chaeyoon Kim, Yeonjae Kim, Bum Sik Chin, Sungmin Jung, Jun Yong Choi, Kyoung-Ho Song, Yong-Dae Kim, Jun-Sun Park, Joon Young Song, Eui-Cheol Shin, Young Ki Choi

학술지명

Cell Reports Medicine

개요

Omicron has become the globally dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, creating additional challenges due to its ability to evade neutralization. Here, we report that neutralizing antibodies against Omicron variants are undetected following COVID-19 infection with ancestral or past SARS-CoV-2 variant viruses or after two-dose mRNA vaccination. Compared with two-dose vaccination, a three-dose vaccination course induces broad neutralizing antibody responses with improved durability against different SARS-CoV-2 variants, although neutralizing antibody titers against Omicron remain low. Intriguingly, among individuals with three-dose vaccination, Omicron breakthrough infection substantially augments serum neutralizing activity against a broad spectrum of SARS-CoV-2 variants, including Omicron variants BA.1, BA.2, and BA.5. Additionally, after Omicron breakthrough infection, memory T cells respond to the spike proteins of both ancestral and Omicron SARS-CoV-2 by producing cytokines with polyfunctionality. These results suggest that Omicron breakthrough infection following three-dose mRNA vaccination induces pan-SARS-CoV-2 immunity that may protect against emerging SARS-CoV-2 variants of concern.

과제정보

[I_2020_001] 신종코로나바이러스감염증 감염인에서 2019-nCoV 연구