구분

내용

논문명

Different maturation of gut microbiome in Korean children

저자정보

Jieun Kim, Erin Kim, Bongyoung Kim, Jinsup Kim, Hyun Ju Lee, Jun-Sun Park, Sehee Hwang, Mina Rho, Hyunjoo Pai

학술지명

Frontiers in Microbiology

개요

Our results indicate that the bacterial proportion of the gut in the population ranging from infants to adul*s forms three clusters: the Ruminococcus-Eubacterium (G1), Bifidobacterium-Escherichia (G2), and Bacteroides-Faecalibacterium (G3) groups. The gut microbiota of infants and toddlers (100% of infants and 85% of toddlers) constituted mostly of G2 and G3 groups, whereas 90% of adul*s showed G1-type gut microbiota. School-aged children showed a transitional gut microbiota composition of both infants and adul*s (31%, 38%, and 31% in G1, G2, and G3, respectively). Notably, the three clusters of microbiota showed significantly different patterns of bacterial diversity (p < 0.001): G2 showed the lowest Shannon index, followed by G3 and G1 (1.41, 2.08, and 2.48, respectively; median Shannon index). When combined with the adul* group, alpha diversity showed a positive correlation with age (R2 = 0.3). Furthermore, clustering the composition of antibiotic resistance genes (ARG) identified two clusters (A1 and A2), and most of G1 (95%) and G3 (80%) belonged to A1. However, G2 showed the least diversity and the highest abundance of ARGs. Nine ARG families showed a significant difference among age groups; three tetracycline resistance genes, tet32, tetO, and tetW, showed a positive correlation, and six other genes, ampC, TEM, ileS, bacA, pmr transferase, and cepA, showed a negative correlation with age.

과제정보

[I_2019_009] 국내 소아 연령의 장세균총 발달 및 장내 resistome 획득에 관한 연구